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The collective expertise of our global team distinguishes OBWB in the field of Intellectual Property Law. We align our best resources to meet each client's specific needs and we treat each matter with the highest degree of attention and care.

Alli Antar, Ph.D.

Alli  Antar , Ph.D.

  • Patent Engineer
  • English
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Dr. Alli Antar is a patent engineer with a background in chemistry, cellular and molecular biology, and physiology. She is an accomplished academic scientist with 25 years of research experience and has expertise in drug (including small molecule) and nutritional studies, transgenic technology, medical devices, and a wide range of biological and chemical assays and scientific laboratory equipment.

Prior to joining OBWB, Dr. Antar was a tenure track Assistant Professor in the Department of Pediatrics, Division of Nutrition at Baylor College of Medicine in Houston, TX. As a Principal Investigator, she independently directed an American Heart Association and U.S. Department of Agriculture-funded scientific laboratory conducting basic and translational biomedical research.

Over the course of her extensive academic career, Dr. Antar established subject matter expertise in the areas of autoimmune and cardiovascular diseases, cellular and whole body metabolism, endocrine/hormone disorders (especially diabetes), enzymology, environmental and toxicological studies, immunology, obesity, pharmacology, and vitamins and nutrients. She is knowledgeable in a wide range of in vivo and in vitro methodologies, having developed many such protocols for her lab.

Dr. Antar brings this breadth of knowledge and insight to her work drafting and prosecuting patents for a wide array of domestic and international clients.  
 
Publications
  • AM Nuotio-Antar, AH Hasty, WJ Kovacs. Quantitation and cellular localization of 11b-HSD1 expression in murine thymus. J Steroid Biochem Mol Biol. 2006 May; 99(2-3):93-9.
  • ML Gruen, V Saraswathi, AM Nuotio-Antar, MR Plummer, KR Coenen, AH Hasty. Plasma insulin levels predict atherosclerotic lesion burden in obese hyperlipidemic mice. Atherosclerosis. 2006 May; 186(1):54-64.
  • AM Nuotio-Antar, DL Hachey, AH Hasty. Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6): E1517-28.
  • MV Li, W Chen, RN Harmancey, AM Nuotio-Antar, M Imamura, P Saha, H Taegtmeyer, L Chan. Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP). Biochem Biophys Res Commun. 2010 May 7; 395(3):395-400. 
  • L Huang, T Belousova, JS Pan, J Du, H Ju, L Lu, P Zhang, LD Truong, A Nuotio-Antar, D Sheikh-Hamad. AKI following conditional and kidney-specific knockdown of stanniocalcin-1. J Am Soc Nephrology. 2014 Oct; 25(10):2303-15.
  • L Lin*, AM Nuotio-Antar*, X Ma, F Liu, M Fiorotto, Y Sun. Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake. J Nutr. 2014 Sep; 144(9):1349-55. *co-first author 
  • P Mehta, AM Nuotio-Antar, CW Smith. γδ T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice. J Leukoc Biol. 2015 Jan; 97(1):121-34.
  • N Witte, M Muenzner, J Rietscher, M Knauer, S Heidenreich, AM Nuotio-Antar, FA Graef, R Fedders, A Tolkachov, I Goehring, M Schupp. The glucose sensor ChREBP links de-novo lipogenesis to PPARγ activity and adipocyte differentiation. Endocrinology. 2015 Nov; 156(11): 4008-4019.
  • AM Nuotio-Antar, N Poungvarin, M Li, M Schupp, M Mohammad, S Gerard, F Zou, L Chan. FABP4-cre mediated expression of constitutively active ChREBP protects against obesity, fatty liver, and insulin resistance. Endocrinology. 2015 Nov; 156(11): 4020-32.
  • Q Mo, J Salley, T Roshan, LA Baer, FJ May, EJ Jaehnig, AC Lehnig, X Guo, Q Tong, AM Nuotio-Antar, F Shamsi, YH Tseng, KI Stanford, MH Chen. Identification and characterization of a supraclavicular brown adipose tissue in mice. JCI Insight. 2017 Jun 2;2(11). pii: 93166.
  • J Couturier, AM Nuotio-Antar, N Agarwal, GK Wilkerson, P Saha, V Kulkarni, SK Lakhashe, J Esquivel, PN Nehete, RM Ruprecht, KJ Sastry, JM Meyer, LR Hill, JE Lake, A Balasubramanyam, DE Lewis. Lymphocytes upregulate CD36 in adipose tissue and liver. Adipocyte. 2019 Dec;8(1):154-163.
  • CR Wooton-Kee, M Robertson, Y Zhou, B Dong, Z Sun, KH Kim, H Liu, Y Xu, N Putluri, P Saha, C Coarfa, DD Moore, and AM Nuotio-Antar*. Metabolic dysregulation in the Atp7b-/-Wilson's disease mouse model. Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2076-2083. *senior corresponding author 
  • PM Masschelin, PK Saha, SA Ochsner, AR Cox, KH Kim, JB Felix, R Sharp, X Li, L Tan, JH Park, L Wang, V Putluri, PL Lorenzi, AM Nuotio-Antar, Z Sun, B Kaipparettu, N Putluri, DD Moore, SA Summers, NJ McKenna, and SM Hartig. Vitamin B2 enables peroxisome proliferator-activated receptor α regulation of fasting glucose availability. Elife. 2023 Jul 7;12:e84077.
  • BC Taylor, LH Steinthal, M Dias, HK Yalamanchili, SA Ochsner, GE Zapata, NR Mehta, NJ McKenna, NL Young, AM Nuotio-Antar*. Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress. Epigenetics Chromatin. 2024 Apr 27;17(1):12. *senior corresponding author
  • D Zhang, Y Zhao, G Zhang, D Lank, S Cooke, S Wang, A Nuotio-Antar, X Tong, L Yin. Suppression of hepatic ChREBP⍺-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH. Mol Metab. 2024 July;85:101957.
  • CR Starr, A Zhylkibayev, O Gorbatyuk, AM Nuotio-Antar, J Mobley, MB Grant, M Gorbatyuk. Glucose-Sensing Carbohydrate Response Element-Binding Protein in the Pathogenesis of Diabetic Retinopathy. Cells. 2025 Jan 13;14(2):107.
  • B.S., Chemistry, The University of the South Sewanee, Tennessee, 1999
  • Ph.D., Molecular Physiology and Biophysics, Vanderbilt University Nashville, Tennessee, 2007
  • Postdoctoral Fellow, Departments of Medicine and Pediatrics, Baylor College of Medicine, Houston, Texas, 2012